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Macrophages and dendritic cells use related mechanisms for processing and presentation of antigens and their epitopes in affiliation with MHC II; B cells use considerably different mechanisms that will probably be described further in B Lymphocytes and Humoral Immunity. For now, we are going to deal with the steps of the method as they pertain to dendritic cells. After a dendritic cell recognizes and attaches to a pathogen cell, the pathogen is internalized by phagocytosis and is initially contained within a phagosome. Lysosomes containing antimicrobial enzymes and chemicals fuse with the phagosome to create a phagolysosome, where degradation of the pathogen for antigen processing begins. APCs do not current all possible epitopes to T cells; only a number of essentially the most antigenic or immunodominant epitopes are offered.

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