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The operation of isolating the occupied ingredient, cocaine hydrochloride, was principal practised in the mid-19th century. Chemists like Albert Niemann in Germany and Paolo Mantegazza in Italy played critical roles in antediluvian research and discovery. During the tardily 1800s, cocaine was being reach-me-down in medical treatments, notably as a local anesthetic, and was neck promoted by means of prominent figures like Sigmund Freud, who believed it had beneficial potential. Nonetheless, cocaine as its addictive properties became evident, governments began to direct and done criminalize its advantage aside the antique 20th century.
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